A determinant of clopidogrel efficacy
نویسندگان
چکیده
منابع مشابه
Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation.
Clopidogrel pharmacotherapy is associated with substantial interindividual variability in clinical response, which can translate into an increased risk of adverse outcomes. Clopidogrel, a recognized substrate of hepatic carboxylesterase 1 (CES1), undergoes extensive hydrolytic metabolism in the liver. Significant interindividual variability in the expression and activity of CES1 exists, which i...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2011
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd3377